That may be because IF participants ate less protein, says Moskovitz, or because they exercised less than the control group. The article was rated one of the most popular among readers after its release on September 28. About half were instructed to eat three meals per day, with snacks allowed, between 7 a.m. and 11 p.m. “We did not tell them how much to eat or what to eat, but it was pitched as a weight-loss study,” says Dr. Weiss. According to Shepherd and the researchers, even more significant was reduction in lean mass in the TRE group. The study also found fasting could lead to a significant loss of muscle mass, leading to weakness and risk of weight regain. In fact, it may even cause you to lose muscle mass. But the bulk of pounds lost wasn't fat. “Intermittent fasting needs to be thoroughly studied given the surprising loss in muscle in this particular study.”. With touted benefits from weight loss to improved insulin resistance—without a complicated regimen involving lots of calorie counting— it’s no wonder many people have gravitated towards the eating plan. Fifty of the participants in the TRE group underwent in-person testing to measure fat and muscle mass, blood sugar levels and energy expenditure. Emergency Information By collaborating with Shepherd’s Shape Up Study, the TREAT study was able to track changes in muscle, visceral fat and other regional body composition measures in 50 local participants. 16-22 The proportion of lean mass loss in this study (approximately 65%) far exceeds the normal range of 20% to 30%. Moskovitz adds that IF isn’t safe for everyone: People with certain serious medical conditions, those who are pregnant or breastfeeding, kids, teens, and people with a history of disordered eating patterns should avoid IF. The most popular type of IF is 16:8 fasting, says Moskovitz, which involves eating within an eight-hour period and then fasting for 16 hours. Leucine is an amino acid and some studies had shown increased release during fasting and other had not. Move over keto, there’s a new eating plan creating controversy: Intermittent fasting (IF), which Forbes named one of the hottest diets of 2020. Experts have promoted its benefits and celebrities from Hugh Jackman to … All rights reserved. (Related: 21 Best Healthy Cooking Hacks of All Time.) “For some, this ‘circadian rhythm’-aligning strategy proves effective, especially if a majority of their empty-calorie eating occurs after dinner,” says Moskovitz. forces the body to release sugar stored in its cells to use for energy. “This is largely due to the impact fasting has on insulin response in the body,” she says. For those tracked in-person, 65% of the weight they lost was due to lean mass loss, more than double of what is considered normal. University of Hawaiʻi Cancer Center researcher John Shepherd worked in collaboration with primary investigator Ethan Weiss, a cardiologist, and graduate student Dylan Lowe, both from the University of California San Francisco, and other colleagues on the Time-Restricted Eating (TREAT) study published in JAMA Internal Medicine. Recent clinical evidence bears out the fact that repeated fasting does not cause muscle loss. IF as a weight loss approach has been around in various forms for ages, but was highly popularized in 2012 by BBC broadcast journalist Dr. Michael Mosley’s TV documentary Eat Fast, Live Longer and book The Fast Diet, followed by journalist Kate Harrison’s book The 5:2 Diet based on her own experience, and subsequently by Dr. Jason Fung’s 2016 bestseller The Obesity Code. There also wasn’t any significant difference in other health markers between groups, including blood pressure, triglyceride levels, total cholesterol levels, fasting glucose levels, or insulin levels. 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